Eight-week cenegermin treatment linked to improved corneal outcomes in NK
An 8-week course of cenegermin was associated with improvements in corneal sensation and corneal innervation in patients with neurotrophic keratopathy, according to a study.
In this analysis, investigators reviewed studies published between August 2018 and June 2024 that evaluated changes in corneal sensation or innervation following cenegermin treatment. A total of 25 studies met inclusion criteria, with a pooled mean patient age of 61.8 years. Most studies included patients with stage II (moderate) and stage III (severe) neurotrophic keratopathy.
Among studies reporting quantitative outcomes, 8 assessed corneal sensation and 3 evaluated corneal innervation. Using sample size–weighted analysis, the mean improvement from baseline to 8 weeks was 116.5% for corneal sensation and 64.5% for corneal innervation.
Reference
Fung SSM, Campos C, Weiss J, et al. Systematic Literature Review on the Effect of Cenegermin on Corneal Sensation and Innervation in Patients with Neurotrophic Keratopathy. J Ocul Pharmacol Ther. 2026;10807683261429005. doi: 10.1177/10807683261429005. Epub ahead of print. PMID: 41852024.
